Case Study: Cancer Patient (46y)
A 46 year-old female suffered from Epidermolysis Bullosa (EB) on her feet due to her chemotherapy and cancer treatment. A classic treatment did not seem to work but after dressing the wounds with L-Mesitran Ointment, positive results were achieved.
The patient was suffering from ovary cancer and receiving chemotherapy. The wounds were initially treated with topical antibiotics and foam dressings to provide an occlusive environment. The medications barely worked.
The medical professionals decided to switch to medical grade honey-based wound dressings with the expectation that debridement and angiogenesis could be stimulated.
Know more about L-Mesitran Ointment?
This ointment contains 48% Medical Grade Honey, medical grade hypoallergenic lanolin, sunflower oil, cod liver oil, Calendula Officinalis, Aloe Barbadensis, Vitamin C & E and Zinc Oxide.. L-Mesitran Ointment is suitable for the treatment of chronic, oncological and acute wounds like abrasions, cuts and burns.
For optimal effect, applying a thin layer is enough. Changing dressings once a day or once every other day is sufficient. The ointment will not adhere to the wound.
Treatment with L-Mesitran Ointment
The wounds on both feet were dressed daily with a thin layer of L-Mesitran Ointment, covered with an occlusive foam dressing. Dressing was changed once per day during the first week, after which the frequency was lowered.
The wounds on the left foot covered an area of approximately 8x4cm and on the right foot,11×4 cm. Within 4 days, the wound started to debride and granulation tissue was seen. The left foot healed in 10 days and the small wound on the right foot healed completely within 17 days.
The patient reported some sensation but not pain during the application or at dressing changes. No adverse effects were observed.
What is Epidermolysis Bullosa?
Epidermolysis bullosa (EB) is a group of mostly genetic disorders that affect the skin and mucous membranes. The condition is characterized by skin that is extremely fragile and easily damaged, causing blistering and painful open sores.
EB can range from mild to severe, and symptoms can vary depending on the type of EB. Some types of EB may also affect other parts of the body, such as the eyes, mouth, and internal organs.
How many types of EB are there?
Allthough more variations are possible, there are four main cases of EB:
- Epidermolysis bullosa simplex: This is the most common type of EB, accounting for about 70% of cases. It causes blistering in the outer layer of skin (the epidermis), and usually does not affect other parts of the body.
- Junctional epidermolysis bullosa: This type of EB is caused by defects in the proteins that hold the layers of skin together. It can cause blistering in the skin and mucous membranes, and may also affect the respiratory and digestive systems.
- Dystrophic epidermolysis bullosa: This type of EB is caused by defects in the protein that anchors the outer layer of skin to the underlying tissue. It can cause blistering and scarring of the skin and may also affect the nails and teeth.
- Kindler syndrome: This is a rare type of EB that affects multiple layers of skin. It can cause blistering and photosensitivity (sensitivity to light) and may also affect the mucous membranes and other organs.
How can you treat EB?
There is currently no cure for Epidermolysis bullosa (EB), but treatment aims to manage symptoms, prevent complications, and improve quality of life. The specific treatment plan will depend on the type and severity of EB, as well as the individual’s age, overall health, and other factors. Here are some common treatment approaches for EB:
- Wound care: This is an essential aspect of managing EB, as the skin is extremely fragile and prone to blistering and injury. Special dressings, bandages, and padding can be used to protect the skin and prevent infections. In some cases, topical or oral antibiotics may be prescribed to treat or prevent infections. However honey can be a better alternative.
- Pain management: The blisters and sores associated with EB can be very painful, and pain management is an important part of treatment. Pain relievers, such as acetaminophen or nonsteroidal anti-inflammatory drugs (NSAIDs), may be used to manage pain. In some cases, stronger pain medications may be needed.
- Nutritional support: People with EB may have difficulty eating and absorbing nutrients, and may require nutritional supplements or specialized diets to maintain adequate nutrition.
- Surgery: In some cases, surgery may be necessary to address complications of EB, such as scarring or contractures (tightening of the skin and underlying tissues).
- Physical therapy: People with EB may benefit from physical therapy to maintain mobility, prevent contractures, and improve overall function.
- Genetic counseling: Since EB is a genetic disorder, genetic counseling may be recommended to help individuals and their families understand the inheritance patterns of the condition, assess the risk of passing it on to children, and explore options for family planning.