Injury Care: Healing a Leg Burn Caused by Motor Outlet

This case study highlights the effective use of L-Mesitran in healing a burn wound in a 71-year-old male. The wound, initially left untreated for a week, showed significant improvement within a few days of treatment. The antimicrobial and wound healing properties of Medical Grade Honey played a crucial role in achieving complete recovery within 20 days.

Patient history

A 71-year-old male burned his leg on the hot outlet of his motorbike. Upon presentation, the wound was present for one week without professional treatment. The general practitioner could not be reached during the weekend and the ambulant care in the peripheral hospital send him home with a regular gauze. Wound progression was limited during the last week and Medical Grade Honey (MGH)-based wound care products of L-Mesitran will subsequently be used.

Upon presentation, wound treatment with L-Mesitran Tulle was started. Since the wound was painful, after the first dressing change it was decided to switch to L-Mesitran FoamL-Mesitran Foam is a little thicker and would also protect better against external mechanical forces as it forms a cushioning layer. Wound dressings were changed every 1-3 days. Wound treatment was continued with L-Mesitran Foam until complete healing was achieved.

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Give Medical Grade Honey after a burn wound, from an exhaust pipe, a 71-year-old male's wound was untreated for a week.

Results after burn wound treatment

Upon presentation, the wound was very red and painful. After three days of treatment, non-viable tissue is autolytic debrided and wound became much more superficial. The wound healing further progresses during the following dressing changes, as can be observed by the increasing granulation tissue formation, and the tissue changing from red into pink color, indicating the healing. In addition, reepithelialization can be observed from the edges of the wound. After 12 days, the wound size significantly decreased and complete healing was achieved at day 20.

Discussion on the effect of Medical Grade Honey

L-Mesitran Foam is a unique product that combines L-Mesitran Soft with a Foam dressing. On itself, L-Mesitran Soft has antimicrobial activity against a wide range of microorganisms and multiple mechanisms that are responsible for promoting wound healing (1, 2).

MGH holds broad range antimicrobial activity via multiple mechanisms; the low pH, strong osmotic action, production of hydrogen peroxide, and presence of antimicrobial molecules. The vitamins C and E that are supplemented have synergistic antimicrobial activity with the raw Medical Grade Honey (1-3). Moreover, both honey and vitamins C and E have shown to possess anti-viral activity, and hence, likely also help to treat cold sores (4-8).

Besides, L-Mesitran has prophylactic activity against infections as recently demonstrated in two randomized controlled studies, showing infection rate was decreased 3-4-fold (9, 10). Complete healing of lacerations was also improved, supporting another important asset: promoting wound healing (10). L-Mesitran enhances wound healing by creating a moist wound environment, promoting autolytic debridement, angiogenesis and reepithelialization. Moreover, oxidative and inflammatory stress are reduced (11-15). These activities suggest L-Mesitran could serve as a putative new therapy for treating cold sores.

L-Mesitran Soft in combination with the foam dressing promotes the absorption of exudate by its osmotic activity. This osmotic activity attracts wound exudate and lymph fluid from deeper tissue, creating an outflow of fluid (16, 17). The attracted wound fluid will subsequently be absorbed by the hydrophilic L-Mesitran Foam dressing that has a high capacity to absorb and retain fluid. This high retention rate is important for exudate management. 

The L-Mesitran Foam creates the optimal level of moisture and prevents maceration as may happen in wet wounds. L-Mesitran Foam delivers the right amount of L-Mesitran Soft to the wound bed, which keeps the wound moist, promotes autolytic debridement, and stimulates granulation tissue formation and reepithelialisation. The MGH forms an important nutrient source for the proliferating skin cells and stimulates neovascularization, which further improves the transport of nutrients and oxygen from the body to the wound bed (16, 17). 

The L-Mesitran Foam is user- and patient-friendly and can easily be cut to the size of the wound where the soft contact material can serve to protect wound edges and prevents injuries from external mechanical forces. No pain or discomfort was experienced during the application or change of the dressings. The L-Mesitran Soft layer prevents newly formed granulation tissue to grow into the dressing and allows pain-free removal without re-opening the wound. The combination of L-Mesitran Soft with a foam dressing is a novelty that can help the healing of a wide variety of exuding wounds.

In conclusion, L-Mesitran was effective to rapidlyheal the presented wound without any complications or adverse events.


  1. Cremers N, Belas A, Santos Costa S, Couto I, de Rooster H, Pomba C. In vitro antimicrobial efficacy of two medical grade honey formulations against common high-risk meticillin-resistant staphylococci and Pseudomonas spp. pathogens. Vet Dermatol. 2020;31(2):90-6.
  2. Oliveira AMP, Devesa JSP, Hill PB. In vitro efficacy of a honey-based gel against canine clinical isolates of Staphylococcus pseudintermedius and Malassezia pachydermatis. Vet Dermatol. 2018;29(3):180-e65.
  3. Hermanns R, Cremers NAJ, Leeming JP, van der Werf ET. Sweet Relief: Determining the Antimicrobial Activity of Medical Grade Honey Against Vaginal Isolates of Candida albicans. J Fungi (Basel). 2019;5(3).
  4. Fedoreyev SA, Krylova NV, Mishchenko NP, Vasileva EA, Pislyagin EA, Iunikhina OV, et al. Antiviral and Antioxidant Properties of Echinochrome A. Mar Drugs. 2018;16(12).
  5. Gaby AR. Natural remedies for Herpes simplex. Altern Med Rev. 2006;11(2):93-101.
  6. Uozaki M, Ikeda K, Tsujimoto K, Nishide M, Yamasaki H, Khamsri B, et al. Antiviral effects of dehydroascorbic acid. Exp Ther Med. 2010;1(6):983-6.
  7. Colunga Biancatelli RML, Berrill M, Catravas JD, Marik PE. Quercetin and Vitamin C: An Experimental, Synergistic Therapy for the Prevention and Treatment of SARS-CoV-2 Related Disease (COVID-19). Front Immunol. 2020;11:1451.
  8. Gustafsson K, Tatz AM, Slavin RA, Dahan R, Ahmad WA, Sutton GA, et al. Will local intraoperative application of Medical Grade Honey in the incision protect against incisional infection in horses undergoing colic surgery? . AAEP Proceedings. 2019;65:387-8.
  9. Mandel HH, Sutton GA, Abu E, Kelmer G. Intralesional application of medical grade honey improves healing of surgically treated lacerations in horses. Equine Vet J. 2020;52(1):41-5.
  10. Nair HKR, Tatavilis N, Pospisilova I, Kucerova J, Cremers NAJ. Medical-Grade Honey Kills Antibiotic-Resistant Bacteria and Prevents Amputation in Diabetics with Infected Ulcers: A Prospective Case Series. Antibiotics (Basel). 2020;9(9).
  11. Smaropoulos E, Cremers NA. Medical grade honey for the treatment of paediatric abdominal wounds: a case series. J Wound Care. 2020;29(2):94-9.
  12. Smaropoulos E, Cremers NAJ. The pro-healing effects of medical grade honey supported by a pediatric case series. Complement Ther Med. 2019;45:14-8.
  13. Smaropoulos E, Cremers NAJ. Treating severe wounds in pediatrics with medical grade honey: A case series. Clin Case Rep. 2020;8(3):469-76.
  14. Smaropoulos E, Cremers NAJ. Medical grade honey for the treatment of extravasation-induced injuries in preterm neonates – a case series. Advances in Neonatal Care. 2020;in press.
  15. Gottrup F. Oxygen in wound healing and infection. World J Surg. 2004;28(3):312-5.
  16. Rossiter K, Cooper AJ, Voegeli D, Lwaleed BA. Honey promotes angiogeneic activity in the rat aortic ring assay. J Wound Care. 2010;19(10):440, 2-6.
  17. Hashemipour MA, Tavakolineghad Z, Arabzadeh SA, Iranmanesh Z, Nassab SA. Antiviral Activities of Honey, Royal Jelly, and Acyclovir Against HSV-1. Wounds. 2014;26(2):47-54.